Steps:

1. Create a measure to show Total Sales
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2. Create A DAX Measure named USA Sales to show all sales made in USA
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USA Sales =
CALCULATE ( [Total Sales] , Region[Location] = "USA" )

3. Create A DAX Measure named Non USA Sales to show all sales made outside the USA
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Non USA Sales =
CALCULATE ( [Total Sales] , Region[Location] <> "USA" )

4. Create A DAX Measure named Last Year Sales to show the Previous Year Sales
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Last Year Sales =
CALCULATE ( [Total Sales] , SAMEPERIODLASTYEAR('Dates'[Date]) )

5. Create A DAX Measure named YoY% to show the percent of Year over Year growth (% difference)
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YoY% =
DIVIDE( [Total Sales] - [Last Year Sales] ,[Last Year Sales] )

6. Create A DAX Measure(s) named Total Profit to show Profit (Total Sales – Cost of Goods Sold) Note: to find Cost of goods sold you must multiply [Cost of Goods] by [Price] – on a row by row basis. In our example the Cost of goods is a percentage of the Sales column. So if a single row has a Sales price of $100 and the Cost Of Goods = 0.8, our actual cost of goods would be $100 * 0.8 = $80. Meaning we would make $20 Revenue on the sale of this single product.
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First, create the column:
Cost of Goods Sold =
SUMX( Sales ,Sales[Sales] * Sales[Cost of Goods] )

Then create the measure:
Total Profit =
[Total Sales] - [Cost of Goods Sold